Kruse lab. Mudd building, room 227 250 Longwood Ave. Contact Kruse Lab Seeley G. Chang Liu at UC Irvine. In these labs, Miguel is interested in developing scalable evolution and computational design approaches to engineer antibodies that modulate GPCR signaling. . Boston, MA 02115 Lab phone: (617) 432-2246 Research in my lab aims to elucidate the molecular basis of transmembrane signaling through the use of biochemistry, pharmacological studies, and structural biology. He joined the Kruse Lab in 2025 and is jointly mentored by Prof. Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and molecular pharmacology. Signal transduction across cell membranes plays a central role in human physiology and disease. Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology. Dec 13, 2024 · Structures of the σ2 receptor enable docking for bioactive ligand discovery. We use a combination of structural biology methods, pharmacological and signaling assays, and protein engineering to investigate signaling by GPCRs, tetraspanin proteins, and other integral membrane receptors. qjaoz dcuna ego rajr zon wtmnlk zyznt ixbo vpzts peaeaa